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Robotics and Biology LaboratoryMahmoud Mabrouk

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Mahmoud Mabrouk

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Raum: MAR 5.065
Telefon: +49.30.314-73118

Forschungsinterressen

  • Proteinstrukturvorhersage
  • Protein Klassifizierung/ Homologiesuche
  • Machinelles Lernen

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Publikationen

Analysis of free modeling predictions by RBO aleph in CASP11
Zitatschlüssel Mabrouk-et-al2016
Autor Mahmoud Mabrouk and Tim Werner and Michael Schneider and Ines Putz and Oliver Brock
Seiten 87–104
Jahr 2016
DOI 10.1002/prot.24950
Journal Proteins: Structure, Function, and Bioinformatics
Jahrgang 84(Suppl 1)
Notiz http://dx.doi.org/10.1002/prot.24950
Zusammenfassung The CASP experiment is a biannual benchmark for assessing protein structure prediction methods. In CASP11, RBO Aleph ranked as one of the top-performing automated servers in the free modeling category. This category consists of targets for which structural templates are not easily retrievable. We analyze the performance of RBO Aleph and show that its success in CASP was a result of its ab initio structure prediction protocol. A detailed analysis of this protocol demonstrates that two components unique to our method greatly contributed to prediction quality: residue–residue contact prediction by EPC-map and contact-guided conformational space search by model-based search (MBS). Interestingly, our analysis also points to a possible fundamental problem in evaluating the performance of protein structure prediction methods: Improvements in components of the method do not necessarily lead to improvements of the entire method. This points to the fact that these components interact in ways that are poorly understood. This problem, if indeed true, represents a significant obstacle to community-wide progress.
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